Peripheral Nerve Regeneration From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies.pdf

                               
登录/注册后可看大图

ITOe | 2017 | ISBN: 9535131664 9789535131663 | 208 Pages | PDF | 25 MB

This volume is dedicated to a comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration; the advances in peripheral nerve repair and future perspectives discussed, including surgeons' and researchers' own large experience in this field of knowledge.

Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients.

Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages.
Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities.
Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents.

Contents
1 Peripheral Nerve Injury and Current Treatment Strategies
2 Peripheral Nerve Entrapment and their Surgical Treatment
3 Nerve Transfers in the Treatment of Peripheral Nerve Injuries
4 Surgical Treatment of Brachial Plexus Injury
5 The Role of Nucleotides in Glial Cells during Peripheral Nerve Trauma and Compressive Disorders
6 The Role of Pharmacological Agents in Nerve Regeneration after Peripheral Nerve Repair
7 Adult and Reparative Neurogenesis in Fish Brain
8 Effect of Local Delivery of GDNF Conjugated Iron Oxide Nanoparticles on Nerve Regeneration along Long Chitosan Nerve Guide