依据艾美仕市场研究公司最新的数据,美国处方量最大和销售额最高的处方药较前没有明显改变。 治疗甲状腺功能减退药物左旋甲状腺素(Synthroid,艾伯维)仍然是全国处方量最大的药物,而抗精神病药物阿立哌唑(Abilify,大冢制药)则继续保持美国销售额最高处方药的桂冠。 这些数据反映了过去12个月期间(2013年07月至2014年06月)美国处方量和销售额前100名药物情况。 作为美国处方量最大药物,过去12个月期间,美国开出了2260万张左旋甲状腺素处方。继左旋甲状腺素钠之后是降胆固醇药物瑞舒伐他汀(Crestor,阿斯利康),大约有2250万张处方;第三名是质子泵抑制剂埃索美拉唑(Nexium,阿斯利康),约有1860万张处方;治疗哮喘药物沙丁胺醇(Ventolin HFA,葛兰素史克)以1750万张处方排名第四;而丙酸氟替卡松/沙美特罗吸入剂(Advair Diskus,葛兰素史克)则以1500万张处方排名第五。 美国处方量最大药物排名前10的其他5种药物分别为:抗高血压药缬沙坦(代文,诺华);降血糖药甘精胰岛素注射液(来得时,赛诺菲安万特);抗抑郁药度洛西汀(欣百达,礼来);治疗注意力缺陷药物二甲磺酸赖右苯丙胺(Vyvanse,夏尔公司);以及抗癫痫药普瑞巴林(Lyrica,辉瑞)。 作为美国销售额最高的处方药,2013年07月至2014年06月期间,阿立哌唑销售额高达72亿美元。其次是关节炎治疗药物阿达木单抗(Humira,艾伯维),63亿美元;埃索美拉唑(Nexium,阿斯利康),63亿美元;瑞舒伐他汀(Crestor,阿斯利康),56亿美元;以及关节炎治疗药物依那西普(恩利,安进公司),接近51亿美元。 美国销售额最高药物排名前10的其他5种药物分别为:丙酸氟替卡松/沙美特罗吸入剂(Advair Diskus,葛兰素史克),50亿美元;抗病毒药索菲布韦(Sovaldi,吉利德公司),44亿美元;关节炎治疗药物英利昔单抗(类克,山陶克公司),43亿美元;降血糖药甘精胰岛素注射液(来得时,赛诺菲安万特),38亿美元;以及中性粒细胞减少症治疗药物聚乙二醇非格司亭(Neulasta,安进公司),接近37亿美元。 表1 美国月处方量前100名药物 排名 | 药名(商品名) | 2013.7–2014.6期间总处方量 | 1 | Synthroid | 22,664,826 | 2 | Crestor | 22,557,735 | 3 | Nexium | 18,656,464 | 4 | Ventolin HFA | 17,556,646 | 5 | Advair Diskus | 15,003,169 | 6 | Diovan | 11,401,503 | 7 | Lantus Solostar | 10,154,739 | 8 | Cymbalta | 10,065,788 | 9 | Vyvanse | 10,019,178 | 10 | Lyrica | 9,684,884 | 11 | Spiriva Handihaler | 9,518,849 | 12 | Lantus | 9,358,961 | 13 | Celebrex | 8,815,391 | 14 | Abilify | 8,777,842 | 15 | Januvia | 8,758,309 | 16 | Namenda | 7,640,319 | 17 | Viagra | 7,584,152 | 18 | Cialis | 7,555,933 | 19 | Zetia | 7,411,629 | 20 | Nasonex | 7,304,210 | 21 | Suboxone | 7,011,882 | 22 | Symbicort | 6,948,403 | 23 | Bystolic | 6,722,578 | 24 | Flovent HFA | 5,623,533 | 25 | Oxycontin | 5,559,330 | 26 | Levemir | 5,554,827 | 27 | Xarelto | 5,014,364 | 28 | Nuvaring | 5,011,966 | 29 | Dexilant | 4,866,178 | 30 | Thyroid | 4,834,481 | 31 | Benicar | 4,725,628 | 32 | Voltaren Gel | 4,709,766 | 33 | Proventil HFA | 4,494,004 | 34 | Tamiflu | 4,149,835 | 35 | Novolog | 4,044,310 | 36 | Novolog Flexpen | 4,006,690 | 37 | Premarin | 3,984,357 | 38 | Vesicare | 3,873,046 | 39 | Humalog | 3,858,256 | 40 | Benicar HCT | 3,633,026 | 41 | Lumigan | 3,283,060 | 42 | Afluria | 3,242,605 | 43 | Lo Loestrin Fe | 3,154,488 | 44 | Janumet | 3,089,749 | 45 | Ortho-Tri-Cy Lo 28 | 3,053,738 | 46 | Toprol-XL | 3,044,003 | 47 | Pristiq | 3,023,546 | 48 | Combivent Respimat | 2,994,490 | 49 | Vytorin | 2,988,460 | 50 | Travatan Z | 2,919,358 | 51 | Focalin XR | 2,866,278 | 52 | Pataday | 2,757,094 | 53 | Humalog Kwikpen | 2,626,530 | 54 | Lunesta | 2,590,519 | 55 | Avodart | 2,527,583 | 56 | Pradaxa | 2,442,678 | 57 | Seroquel XR | 2,405,130 | 58 | Strattera | 2,387,756 | 59 | Minastrin 24 Fe | 2,353,282 | 60 | Evista | 2,232,555 | 61 | Chantix | 2,151,879 | 62 | Zostavax | 2,145,562 | 63 | Humira | 1,923,427 | 64 | Victoza 3-Pak | 1,902,995 | 65 | Exelon | 1,877,942 | 66 | Exforge | 1,838,730 | 67 | Combigan | 1,821,491 | 68 | Dulera | 1,790,677 | 69 | Onglyza | 1,784,018 | 70 | Welchol | 1,778,218 | 71 | Premarin Vaginal | 1,718,405 | 72 | Enbrel | 1,627,480 | 73 | Xopenex HFA | 1,588,895 | 74 | Ranexa | 1,567,961 | 75 | Truvada | 1,532,734 | 76 | Alphagan P | 1,503,194 | 77 | Viibryd | 1,447,730 | 78 | Tradjenta | 1,443,791 | 79 | Effient | 1,434,572 | 80 | Azor | 1,433,045 | 81 | Norvir | 1,384,306 | 82 | Actonel | 1,339,615 | 83 | Namenda XR | 1,319,963 | 84 | Amitiza | 1,309,980 | 85 | Aggrenox | 1,286,826 | 86 | Lotemax | 1,276,480 | 87 | Patanol | 1,274,050 | 88 | Levitra | 1,273,311 | 89 | Advair HFA | 1,272,551 | 90 | Uloric | 1,244,536 | 91 | Detrol La | 1,225,506 | 92 | Asmanex Twisthaler | 1,219,112 | 93 | Lipitor | 1,212,376 | 94 | Atripla | 1,183,636 | 95 | Prempro Low Dose | 1,162,513 | 96 | Latuda | 1,123,396 | 7 | Novolog Flxpen Mix 70/30 | 1,119,855 | 98 | Invokana | 1,106,268 | 99 | Epiduo | 1,103,330 | 100 | Humulin N | 1,071,673 |
表1 美国销售额前100名药物 排名 | 药名(商品名) | 2013.7–2014.6期间总销售额 | 1 | Abilify | $7,240,043,661 | 2 | Humira | $6,310,742,887 | 3 | Nexium | $6,303,738,580 | 4 | Crestor | $5,672,991,435 | 5 | Enbrel | $5,097,263,350 | 6 | Advair Diskus | $5,064,138,456 | 7 | Sovaldi | $4,469,558,675 | 8 | Remicade | $4,342,356,359 | 9 | Lantus Solostar | $3,829,943,226 | 10 | Neulasta | $3,688,450,342 | 11 | Copaxone | $3,677,307,402 | 12 | Rituxan | $3,361,247,463 | 13 | Spiriva Handihaler | $3,270,501,346 | 14 | Januvia | $3,124,826,108 | 15 | Lantus | $3,011,654,746 | 16 | Atripla | $2,898,264,003 | 17 | Cymbalta | $2,839,722,673 | 18 | Avastin | $2,784,813,413 | 19 | Lyrica | $2,782,036,977 | 20 | Oxycontin | $2,524,152,087 | 21 | Celebrex | $2,435,800,107 | 22 | Epogen | $2,378,212,523 | 23 | Truvada | $2,351,681,656 | 24 | Diovan | $2,177,824,165 | 25 | Levemir | $2,121,663,090 | 26 | Gleevec | $2,087,891,457 | 27 | Herceptin | $2,032,270,434 | 28 | Vyvanse | $1,940,313,035 | 29 | Lucentis | $1,932,528,073 | 30 | Zetia | $1,930,143,528 | 31 | Tecfidera | $1,908,407,807 | 32 | Symbicort | $1,901,446,790 | 33 | Namenda | $1,774,338,290 | 34 | Novolog Flexpen | $1,720,294,797 | 35 | Xarelto | $1,546,602,955 | 36 | Novolog | $1,466,291,783 | 37 | Humalog | $1,418,795,789 | 38 | Suboxone | $1,388,999,843 | 39 | Tysabri | $1,315,848,323 | 40 | Viagra | $1,274,239,087 | 41 | Seroquel XR | $1,266,841,322 | 42 | Victoza 3-Pak | $1,263,623,179 | 43 | Cialis | $1,241,580,547 | 44 | Stelara | $1,221,329,301 | 45 | Alimta | $1,215,044,019 | 46 | Nasonex | $1,190,958,069 | 47 | Avonex | $1,146,712,504 | 48 | Gilenya | $1,143,648,903 | 49 | Humalog Kwikpen | $1,140,418,800 | 50 | Flovent HFA | $1,091,998,384 | 51 | Prezista | $1,079,469,740 | 52 | Janumet | $1,071,110,813 | 53 | Renvela | $1,063,062,816 | 54 | Isentress | $1,045,929,798 | 55 | Procrit | $1,028,448,101 | 56 | Orencia | $1,017,584,725 | 57 | Dexilant | $1,010,512,519 | 58 | Vesicare | $1,001,127,504 | 59 | Stribild | $962,264,200 | 60 | Olysio | $943,547,154 | 61 | Synthroid | $927,886,999 | 62 | Neupogen | $922,013,084 | 63 | Avonex Pen | $920,097,484 | 64 | Reyataz | $918,922,508 | 65 | Zytiga | $918,603,420 | 66 | Xolair | $902,375,287 | 67 | Invega Sustenna | $891,518,099 | 68 | Benicar | $884,750,288 | 69 | Combivent Respimat | $881,992,234 | 70 | Pradaxa | $879,463,846 | 71 | Sensipar | $878,283,696 | 72 | Xgeva | $844,140,641 | 73 | Vytorin | $828,020,808 | 74 | Betaseron | $824,758,830 | 75 | Aranesp | $824,531,232 | 76 | Prevnar 13 | $818,701,788 | 77 | Latuda | $803,311,039 | 78 | Afinitor | $800,598,342 | 79 | Lunesta | $778,412,409 | 80 | Ventolin HFA | $771,201,081 | 81 | Complera | $756,268,942 | 82 | Synagis | $754,510,179 | 83 | Bystolic | $736,654,176 | 84 | Zyvox | $733,964,492 | 85 | Gardasil | $717,881,961 | 86 | Sandostatin Lar | $715,506,378 | 87 | Benicar HCT | $699,679,537 | 88 | Treanda | $692,288,820 | 89 | Pristiq | $687,192,710 | 90 | Zostavax | $674,280,328 | 91 | Erbitux | $669,382,439 | 92 | Cimzia | $660,599,949 | 93 | Strattera | $658,818,959 | 94 | Cubicin | $655,269,663 | 95 | Xeloda | $652,443,257 | 96 | Tarceva | $638,909,500 | 7 | Evista | $638,155,000 | 98 | Velcade | $636,704,153 | 99 | Sprycel | $635,192,399 | 100 | Abraxane | $634,678,206 |
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